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I always wonder if some of the self reported dosage variability for pills comes from differences in absorbtion of pills. Maybe some ppl's stomach acids or bacterial flora destroy particular molecules more or prevents absorption more than in other ppl?


Sublingual tablets are available which result in a much more reliably fast absorption. I recommend them for anyone who wants less variability from their melatonin use.


Any links on why are sublingual better wrt absorption?


It bypasses the stomach and intestines. It also bypasses liver metabolism (first-pass metabolism)

https://en.wikipedia.org/wiki/Sublingual_administration#Prin...

https://en.wikipedia.org/wiki/First_pass_effect


Short answer is because the chemical goes directly through the membrane into the bloodstream.

https://en.m.wikipedia.org/wiki/Sublingual_administration


you can see this with pot edibles, if you take one on an empty stomach it takes forever to kick in and sometimes doesn’t work very well, but if you eat the same one after a large fatty meal it will kick in fast and strong




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