From competitive cycling perspective GLP1 drugs are not helpful, least of all at the highest levels of sport where doping would be a concern that actually gets testing and enforcement.
When I was at the peak of my training, it was legitimately hard to get enough calories. I had days where my caloric intake was approaching 5000kcal (long zone 2 rides). When you're doing that kind of metabolic load, being unable to consume the calories you need means being unable to recover properly.
Outside weight-class or aesthetics-driven sports, it’s hard to imagine any scenario where a GLP-1 analog creates a net advantage.
In endurance disciplines the binding constraint is almost always fuel throughput: if an athlete can’t take in and process enough calories, recovery and performance fall apart. Anything that suppresses appetite or slows gastric motility is basically disqualifying.
You can already see how narrow that margin is in the sheer amount of gels, bars, and mixes riders consume during long sessions.
From that angle, GLP-1 simply doesn’t occupy the same decision space as substances that expand performance capacity or recovery bandwidth.
The message I got was more "decentralized services have major coordination issues that prevent them from adapting to changing needs".
Also a major point in Signal's development philosophy is building a comms platform that doesn't require that you trust them, because the protocol is built in a way that leaks the absolute minimum of data about the user necessary to make the service usable for the general public.
Just gave it a listen. A lot of what he asserts seems pretty obvious with many examples e.g. the ones he give about IP, DNS, email etc. Centralized movers will always have the advantage of coordination, so decentralized systems have to have a damn good raison d'etre that's immediately obvious (e.g. Tor) or else be eventually consigned to niche use in highly idealistic communities.
Great question. Let’s take a deep dive on money. Getting $100 at the right time can be a game-changer! It’s not only a store of value — it’s a means of exchange!
Second paragraph mentions "regulatory restrictions".
Clinuvel Pharmaceuticals intended to offer it as a cosmetic, but abandoned this pursuit in the 2000s due to regulatory restrictions and concerns about the promotion of suntanning. Unlicensed Melanotan II is found on the internet, although health agencies advise against its use due to lack of testing and regulatory approval.
reply